Autoregulated paracellular clearance of amyloid-b across the blood-brain barrier
نویسندگان
چکیده
Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland. Laboratory for Neurodegenerative Research, Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland. UCD School of Veterinary Medicine and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. Ross University School of Veterinary Medicine, P. O. Box 334, Basseterre, St. Kitts, West Indies. *Corresponding author. E-mail: [email protected]
منابع مشابه
Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier
The blood-brain barrier (BBB) is essential for maintaining brain homeostasis and protecting neural tissue from damaging blood-borne agents. The barrier is characterized by endothelial tight junctions that limit passive paracellular diffusion of polar solutes and macromolecules from blood to brain. Decreased brain clearance of the neurotoxic amyloid-β (Aβ) peptide is a central event in the patho...
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تاریخ انتشار 2015